Finding a cure for Alpha-1 and improving the lives of those affected

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OUR IMPACT

We’ve invested over $100 million into Alpha‑1 research and related programs

From funding breakthrough research to hosting programs and events that keep our community strong and healthy until we find a cure, no other organization does more for families with Alpha‑1.

$100M

in research funded

130

researchers funded

10X

the clinical trials within a decade

TOP STORIES

Guidance for Alphas on Adult Seasonal Respiratory Vaccines

It is important for Alphas to be up-to-date on their seasonal vaccines. AlphaNet has provided a chart to keep you […]

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September 26, 2025
Alphas Go to Washington, DC: Momentum Builds for Home Infusion and Oxygen Access

Early September, Alpha-1 Foundation (A1F) advocates from across the country gathered in Washington, DC, for a Lobby Day bringing the […]

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September 26, 2025
A1F Endorses Safe Step Act Patient Protection Bill

The Alpha-1 Foundation proudly joins the broad coalition of more than 200 organizations endorsing the Safe Step Act and stand […]

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September 25, 2025
A1F Joins Advocacy Groups in Signing Congressional Letter on Rare Pediatric Program

Below is the official letter addressed to key leaders in the U.S. Senate and House of Representatives urging support for […]

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September 12, 2025
Alpha-1 Foundation Launches Innovative New Model for Centralized Detection

The Alpha-1 Foundation (A1F) is excited to announce the formation of AlphaDetect, a new non-profit subsidiary of A1F, to lead a […]

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August 20, 2025
July 2025 PubMed Articles

The Alpha-1 Foundation is proud to provide a monthly list of articles from researchers that have been funded by the […]

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August 19, 2025
Alpha-1 Foundation Honors Kenneth and Bettina Irvine at Annual Golf Invitational

The Alpha-1 Foundation’s annual Bettina B. Irvine Golf Invitational returned to Greenwich on May 28th, raising critical funds and awareness […]

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July 31, 2025
Alpha, Betsy Scher Shares Sweet Support for Alpha-1

Monday, July 21st, 2025- Betsy Scher and The Highland Park, Illinois community came together in the sweetest way—at Ice Cream […]

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July 29, 2025
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SPOTLIGHT

A1F Riding for a Reason

Dr. Jennifer Sherman is celebrating her 50th birthday by joining A1F Riding for a Reason for the first time, cruising on her pink tricycle to raise awareness and funds for Alpha-1!

Throughout September, A1F Riding for a Reason is uniting riders, families, and supporters nationwide in honor of Fred C. Walsh’s legacy and A1F’s 30th Anniversary. From local bike paths to signature treks like Escape to the Cape (Sept. 26–28) and Gulf Coast (Oct. 18), participants ride to honor loved ones, advance research, and celebrate three decades of progress.

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