November PubMed Articles

The Alpha-1 Foundation is proud to provide a monthly list of articles from researchers that have been funded by the Foundation. This list has the most A1F-funded researchers this year.

Below are the top articles for November 2025:

A Compact Base Editor Rescues AATD-Associated Liver and Lung Disease in Mouse Models

• Terence Flotte

The Mechanism of Pathogenic α1-Antitrypsin Aggregation in the Human Liver

• James A. Irving
• David Lomas

 Patient-reported Outcome Measures for Use in Patients with Alpha-1-Antitrypsin Deficiency: Results of a Systematic Selection Process

• Pavel Strnad

 Lung Disease in Never-Smokers with Severe α1-antitrypsin Deficiency: The EARCO Registry

• Mark Brantly
• Nazli Khodayari

 Seasonal Changes in Circulating Alpha-1 Antitrypsin Are Altered by Sex and Genetic Deficiency

• Ilaria Ferrarotti
• Alice Turner
• Marc Miravitlles
• Miriam Barrecheguren

Different Regulation of Alpha-1 Antitrypsin Production in Neutrophils of ZZ-AATD Patients Under Hypoxic Conditions

• Maria Magallón
• Francisco Dasi

Pioglitazone Reduces Hepatic α-1 Antitrypsin Accumulation through Autophagy and AMPK Activation in α-1 Antitrypsin-Deficient Mice

• Mark Brantly
• Nazli Khodayari

Matrix Metalloproteinases and Disease Severity Among PI*MZ and PI*ZZ Individuals in the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) Cohort

• Vickram Tejwani
• Russell Bowler
• Karina Serban
• Victor Ortega
• James Stoller
• Charlie Strange

The Phenotypic State of Biallelic SERPINA1 Q0 Variants in α1-Antitrypsin Deficiency

• Ilaria Ferrarotti