Research funded by the Alpha-1 Foundation (A1F) has greatly improved our understanding of the biological underpinnings and clinical manifestations of Alpha-1 and has identified novel drug targets likely to lead to new therapeutic solutions.
Research Grantee Spotlight
Jeffrey Teckman, MD
Saint Louis University School of Medicine
Funding from the Alpha-1 Foundation has led to important discoveries in Alpha-1 related liver disease
Dr. Teckman’s research with the Alpha-1 Liver Initiative focuses on adult Alphas, and his work with the Childhood Liver Disease Research and Education Network (ChiLDREN) focuses on rare pediatric liver disease. In 2022, Dr. Teckman’s work alongside industry partners, and with A1F funding, led to the discovery of a potential treatment for liver disease associated with Alpha-1.
The Alpha-1 Foundation offers opportunities for data sharing among researchers supported by A1F grants and contracts through our DNA and Tissue Bank and Research Registry
2024 In-Cycle Grant Recipients
2024 Research Grants
Adel El Boueiz, M.D.
Brigham and Women’s Hospital, Inc.
Imaging and Multi-omics Analyses of Emphysema Patterns in MM and MZ smokers
Bibek Gooptu, M.D., Ph.D.
University of Leicester
Structural Studies of Misfolded and Polymeric Alpha1-Antitrypsin in ERAD and ERLAD
James Irving Ph.D.
University College London
Rational Design of Better Diagnostic Reagents
Lela Lackey, Ph.D.
Clemson University
Misregulation of Polyadenylation during Stress Contributes to A1AT Deficiency Phenotypes
Jungnam Lee. Ph.D.
University of Florida
Mechanisms of a-Defensins Mediated Bacterial Infection in AATD Individuals
Nunzia Pastore, Ph.D.
Fondazione Telethon ETS
Revealing the Role of Lysosomes in the Pathology of the AATD-Related Liver Disease
Carmine Settembre, Ph.D.
Fondazione Telethon ETS
Exploring the Role of FAM134B-MEDIATED ER-PHAGY in Alpha-1 Antitrypsin Deficiency
Richard Sifers, Ph.D.
Baylor College of Medicine
Identification of ESLD Prognostic indicators
2024 Pilot and Feasibility Grant
Ariel Curiale, Ph.D.
Brigham and Women’s Hospital, Inc.
AI Approaches to Define Emphysema Progression Risk in PiMZ and PiMS Heterozygous Subjects
Emer Reeves, Ph.D.
Royal College of Surgeons in Ireland
Exploring Pro-Resolving Lipid Complexes to Realize the Full Therapeutic Impact of Alpha-1
