Finding a cure for Alpha-1 and improving the lives of those affected

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OUR IMPACT

We’ve invested over $100 million into Alpha‑1 research and related programs

From funding breakthrough research to hosting programs and events that keep our community strong and healthy until we find a cure, no other organization does more for families with Alpha‑1.

$100M

in research funded

130

researchers funded

10X

the clinical trials within a decade

TOP STORIES

Salazar Reintroduces Bill To Expand Home Infusions For Medicare Beneficiaries With Rare Genetic Disease

On behalf of the Alpha-1 Foundation and entire patient community, we are thrilled with the announcement of the reintroduction of […]

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March 27, 2025
Korro Bio provides update on progress made: KRRO-110

Korro Bio has completed the dosing of the first two single ascending dose cohorts in healthy adult volunteers. They continue […]

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March 19, 2025
The Celtic Connection honors St. Patrick’s Day and the Legacy of Fred C. Walsh  

Today, St. Patrick’s Day is celebrated annually on March 17. Today, people of all backgrounds celebrate St. Patrick’s Day, especially […]

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March 17, 2025
Honoring Pulmonary Awareness Week: Benefits for Alpha-1 Patients

This week marks Pulmonary Rehabilitation Awareness Week, a time to highlight beneficial programs and resources that help people with lung […]

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March 13, 2025
Nature Genetics: Alpha-1 Research Publication March 2025

Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 antitrypsin deficiency “This exciting study provides evidence of […]

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March 12, 2025
Mutated DNA Restored to Normal in Gene Therapy Advance

Exciting breakthrough in Alpha-1 research by Beam Therapeutics shows success in restoring the mutated Alpha-1 gene to normal. This correction […]

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March 11, 2025
A1F Honors Rare Disease Day 2025: A Day of Advocacy, Awareness, and Action

On Friday, February 28th, 2025, the Alpha-1 Foundation (A1F) celebrated Rare Disease Day, bringing the entire community together in various […]

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March 5, 2025
The Celtic Connection is coming up… Get out your green attire! 

The 17th Annual Celtic Connection will take place on Saturday, March 8, 2025, at the Newton Marriott in Boston, Massachusetts. The […]

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February 24, 2025
Letter to the Honorable Pam Bondi, Attorney General of the United States

Alpha-1 Foundation signs on with over 150 stakeholders, emphasizing the importance of telemedicine to Attorney General Pam Bondi.  February 20, […]

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February 20, 2025
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SPOTLIGHT

Raising Alpha-1 Awareness on a Global Scale

Jennifer MacDonald, a lung-affected Alpha, is dedicated to raising Alpha-1 awareness in Mexico and Latin America. In 2023, she attended the A1F 6th Global Research Conference and 9th Patient Congress in Dublin, Ireland, and looks forward to returning to this year’s conference in Lisbon in April.

For Jennifer, attending global Alpha-1 conferences is a powerful opportunity to connect with Alphas and experience the strength of community support. The insights shared by speakers have left a lasting impact, giving her inspiration and building her resilience.

Learn more about the A1F 7th Global Research Conference & 10th Patient Congress

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