Finding a cure for Alpha-1 and improving the lives of those affected

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OUR IMPACT

We’ve invested over $100 million into Alpha‑1 research and related programs

From funding breakthrough research to hosting programs and events that keep our community strong and healthy until we find a cure, no other organization does more for families with Alpha‑1.

$100M

in research funded

130

researchers funded

10X

the clinical trials within a decade

TOP STORIES

The Alpha-1 community mourns the loss of Gordon E. Cadgwan Jr., PhD 

Gordon Cadwgan, PhD passed away peacefully on Saturday, November 29, 2025, at 81 years old surrounded by his family. Gordon […]

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December 1, 2025
Alpha-1 Awareness Month: Week 4 Recap  

This week showcased the heart, dedication, and spirit of the Alpha-1 community as everyone raised awareness; teams and supporters walked, […]

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November 25, 2025
Alpha-1 EU Awareness Event 

A1F’s role as the global leader among the world’s Alpha-1 community was highlighted recently at an Alpha-1 Awareness Month Recognition […]

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November 25, 2025
A1F Virtual Walk – Week 3 Recap 

Week 3 brought heartfelt stories, new beginnings, and meaningful moments from teams and walkers across the United States. Each walk and […]

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November 19, 2025
Dr. Virginia Clark findings from comparison of VCTE FibroScan to Liver Biopsy 

Clark reviews findings from a 3-year longitudinal study comparing VCTE to liver biopsy for staging F2/F3 fibrosis in patients with […]

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November 18, 2025
October PubMed Articles

The Alpha-1 Foundation is proud to provide a monthly list of articles from researchers that have been funded by the […]

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November 18, 2025
September PubMed Articles

The Alpha-1 Foundation is proud to provide a monthly list of articles from researchers that have been funded by the […]

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November 18, 2025
August PubMed Articles

The Alpha-1 Foundation is proud to provide a monthly list of articles from researchers that have been funded by the […]

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November 18, 2025
NORD Webinar: Open Enrollment Essentials for Rare Disease Families

Health insurance is changing …are you ready? Join us on Nov. 19 at 2 p.m. ET for a Zoom webinar […]

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November 13, 2025
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SPOTLIGHT

Forward Together

For two years, Siobhan struggled with declining exercise tolerance and no explanation. A cardiologist finally recommended testing for Alpha-1 Antitrypsin Deficiency (Alpha-1), and the diagnosis provided the answers she desperately needed, transforming fear into clarity and a path forward.

“I inherited the ZZ genes, which are the most deficient, and although a bit scary at first, the Alpha-1 Foundation was extremely encouraging, showing immediate support and guidance,” says Siobhan.

Your generosity helps fund the research and programs that give Siobhan a hopeful future and the support that reminds her that she is not alone.

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